Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Early Alzheimer's disease pathology in human cortex involves transient cell states.

Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, S J; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli-Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna-Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z.

Cell ; 186(20): 4438-4453.e23, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774681

2.

GABA-receptive microglia selectively sculpt developing inhibitory circuits.

Favuzzi, Emilia; Huang, Shuhan; Saldi, Giuseppe A; Binan, Loïc; Ibrahim, Leena A; Fernández-Otero, Marian; Cao, Yuqing; Zeine, Ayman; Sefah, Adwoa; Zheng, Karen; Xu, Qing; Khlestova, Elizaveta; Farhi, Samouil L; Bonneau, Richard; Datta, Sandeep Robert; Stevens, Beth; Fishell, Gord.

Cell ; 184(15): 4048-4063.e32, 2021 07 22.

Artigo em Inglês | MEDLINE | ID: mdl-34233165

3.

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.

Dolan, Michael-John; Therrien, Martine; Jereb, Sasa; Kamath, Tushar; Gazestani, Vahid; Atkeson, Trevor; Marsh, Samuel E; Goeva, Aleksandrina; Lojek, Neal M; Murphy, Sarah; White, Cassandra M; Joung, Julia; Liu, Bingxu; Limone, Francesco; Eggan, Kevin; Hacohen, Nir; Bernstein, Bradley E; Glass, Christopher K; Leinonen, Ville; Blurton-Jones, Mathew; Zhang, Feng; Epstein, Charles B; Macosko, Evan Z; Stevens, Beth.

Nat Immunol ; 24(8): 1382-1390, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37500887

4.

A Milieu Molecule for TGF-ß Required for Microglia Function in the Nervous System.

Qin, Yan; Garrison, Brian S; Ma, Wenjiang; Wang, Rui; Jiang, Aiping; Li, Jing; Mistry, Meeta; Bronson, Roderick T; Santoro, Daria; Franco, Charlotte; Robinton, Daisy A; Stevens, Beth; Rossi, Derrick J; Lu, Chafen; Springer, Timothy A.

Cell ; 174(1): 156-171.e16, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29909984

5.

Microglia and the Brain: Complementary Partners in Development and Disease.

Hammond, Timothy R; Robinton, Daisy; Stevens, Beth.

Annu Rev Cell Dev Biol ; 34: 523-544, 2018 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-30089221

6.

GABA-receptive microglia selectively sculpt developing inhibitory circuits.

Favuzzi, Emilia; Huang, Shuhan; Saldi, Giuseppe A; Binan, Loïc; Ibrahim, Leena A; Fernández-Otero, Marian; Cao, Yuqing; Zeine, Ayman; Sefah, Adwoa; Zheng, Karen; Xu, Qing; Khlestova, Elizaveta; Farhi, Samouil L; Bonneau, Richard; Datta, Sandeep Robert; Stevens, Beth; Fishell, Gord.

Cell ; 184(22): 5686, 2021 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-34715023

7.

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Loh, Ken H; Stawski, Philipp S; Draycott, Austin S; Udeshi, Namrata D; Lehrman, Emily K; Wilton, Daniel K; Svinkina, Tanya; Deerinck, Thomas J; Ellisman, Mark H; Stevens, Beth; Carr, Steven A; Ting, Alice Y.

Cell ; 166(5): 1295-1307.e21, 2016 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-27565350

8.

Shedding light on glioma growth.

Lehrman, Emily K; Stevens, Beth.

Cell ; 161(4): 704-6, 2015 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-25957677

9.

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.

Pinho-Ribeiro, Felipe A; Deng, Liwen; Neel, Dylan V; Erdogan, Ozge; Basu, Himanish; Yang, Daping; Choi, Samantha; Walker, Alec J; Carneiro-Nascimento, Simone; He, Kathleen; Wu, Glendon; Stevens, Beth; Doran, Kelly S; Levy, Dan; Chiu, Isaac M.

Nature ; 615(7952): 472-481, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36859544

10.

Immune Signaling in Neurodegeneration.

Hammond, Timothy R; Marsh, Samuel E; Stevens, Beth.

Immunity ; 50(4): 955-974, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30995509

11.

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Hammond, Timothy R; Dufort, Connor; Dissing-Olesen, Lasse; Giera, Stefanie; Young, Adam; Wysoker, Alec; Walker, Alec J; Gergits, Frederick; Segel, Michael; Nemesh, James; Marsh, Samuel E; Saunders, Arpiar; Macosko, Evan; Ginhoux, Florent; Chen, Jinmiao; Franklin, Robin J M; Piao, Xianhua; McCarroll, Steven A; Stevens, Beth.

Immunity ; 50(1): 253-271.e6, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-30471926

12.

Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.

Rueda-Carrasco, Javier; Sokolova, Dimitra; Lee, Sang-Eun; Childs, Thomas; Jurcáková, Natália; Crowley, Gerard; De Schepper, Sebastiaan; Ge, Judy Z; Lachica, Joanne I; Toomey, Christina E; Freeman, Oliver J; Hardy, John; Barnes, Samuel J; Lashley, Tammaryn; Stevens, Beth; Chang, Sunghoe; Hong, Soyon.

EMBO J ; 42(19): e113246, 2023 Oct 04.

Artigo em Inglês | MEDLINE | ID: mdl-37575021

13.

Neuron-Glia Signaling in Synapse Elimination.

Wilton, Daniel K; Dissing-Olesen, Lasse; Stevens, Beth.

Annu Rev Neurosci ; 42: 107-127, 2019 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-31283900

14.

Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases.

Yvanka de Soysa, T; Therrien, Martine; Walker, Alicia C; Stevens, Beth.

Semin Immunol ; 60: 101651, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-36155944

15.

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.

Scott-Hewitt, Nicole; Perrucci, Fabio; Morini, Raffaella; Erreni, Marco; Mahoney, Matthew; Witkowska, Agata; Carey, Alanna; Faggiani, Elisa; Schuetz, Lisa Theresia; Mason, Sydney; Tamborini, Matteo; Bizzotto, Matteo; Passoni, Lorena; Filipello, Fabia; Jahn, Reinhard; Stevens, Beth; Matteoli, Michela.

EMBO J ; 39(16): e105380, 2020 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-32657463

16.

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.

Li, Tao; Chiou, Brian; Gilman, Casey K; Luo, Rong; Koshi, Tatsuhiro; Yu, Diankun; Oak, Hayeon C; Giera, Stefanie; Johnson-Venkatesh, Erin; Muthukumar, Allie K; Stevens, Beth; Umemori, Hisashi; Piao, Xianhua.

EMBO J ; 39(16): e104136, 2020 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-32452062

17.

CSMD1 regulates brain complement activity and circuit development.

Baum, Matthew L; Wilton, Daniel K; Fox, Rachel G; Carey, Alanna; Hsu, Yu-Han H; Hu, Ruilong; Jäntti, Henna J; Fahey, Jaclyn B; Muthukumar, Allie K; Salla, Nikkita; Crotty, William; Scott-Hewitt, Nicole; Bien, Elizabeth; Sabatini, David A; Lanser, Toby B; Frouin, Arnaud; Gergits, Frederick; Håvik, Bjarte; Gialeli, Chrysostomi; Nacu, Eugene; Lage, Kasper; Blom, Anna M; Eggan, Kevin; McCarroll, Steven A; Johnson, Matthew B; Stevens, Beth.

Brain Behav Immun ; 119: 317-332, 2024 Mar 27.

Artigo em Inglês | MEDLINE | ID: mdl-38552925

18.

Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.

Schafer, Dorothy P; Stevens, Beth.

Immunity ; 42(4): 600-2, 2015 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-25902477

19.

A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis.

Mifflin, Lauren; Hu, Zhirui; Dufort, Connor; Hession, Cynthia C; Walker, Alec J; Niu, Kongyan; Zhu, Hong; Liu, Nan; Liu, Jun S; Levin, Joshua Z; Stevens, Beth; Yuan, Junying; Zou, Chengyu.

Proc Natl Acad Sci U S A ; 118(13)2021 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-33766915

20.

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

Liddelow, Shane A; Marsh, Samuel E; Stevens, Beth.

Trends Immunol ; 41(9): 820-835, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32819809

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Early Alzheimer's disease pathology in human cortex involves transient cell states.

GABA-receptive microglia selectively sculpt developing inhibitory circuits.

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.

A Milieu Molecule for TGF-ß Required for Microglia Function in the Nervous System.

Microglia and the Brain: Complementary Partners in Development and Disease.

GABA-receptive microglia selectively sculpt developing inhibitory circuits.

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Shedding light on glioma growth.

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.

Immune Signaling in Neurodegeneration.

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.

Neuron-Glia Signaling in Synapse Elimination.

Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases.

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.

CSMD1 regulates brain complement activity and circuit development.

Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.

A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis.

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?